| Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic |
| Lu, Qianyun; Wang, Xiaotong; Fan, Xin; Lin JG(林金国) ; Hu, Jiayi; Duan, Guangxin; Yu, Huimin; Geng, Zihan; Wang, Xingang; Dai, Hongliang; Liu F(刘峰); Wen, Ling; Geng, Hongya
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| Corresponding Author | Dai, Hongliang(daihongliang@just.edu.cn)
; Liu, Feng(liufeng@imech.ac.cn)
; Wen, Ling(wenling@suda.edu.cn)
; Geng, Hongya(geng.hongya@sz.tsinghua.edu.cn)
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| Source Publication | ADVANCED HEALTHCARE MATERIALS
(IF:6.27[JCR-2018],6.295[5-Year]) |
| 2024-06-16
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| Pages | 13 |
| ISSN | 2192-2640
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| Abstract | Compromises between enhanced on-targeting reactivity and precise real-time monitoring in the tumor microenvironment (TME) are the main roadblocks for catalytic cancer therapy. The hallmark of a high level of hydrogen peroxide (H2O2) and acidic extracellular environment of the hypoxia solid tumor can underpin therapeutic and tracking performance. Herein, this work provides an activatable wintersweet-like nanohybrid consisting of titanium (Ti) doped cerium vanadate nanorods with the modification of polypyrrole (PPy) nanoparticles (CeVO4-Ti@PPy) for combinatorial therapies of breast carcinoma. The Ti dopants in the size-controllable CeVO4 nanorods lower the energy barrier (0.5 eV) of the rate-determining steps and elaborate peroxidase-like (POD-like) activities to improve the generation of toxic hydroxyl radical (OH) according to the density functional theory (DFT) calculation. The multiple enzyme-like activities, including the intrinsic glutathione peroxidase (GPx) and catalase (CAT), achieve a record-high therapeutic efficiency. Coupling this oxidative stress with the photothermal effects of PPy enables enhanced catalytic tumor necrosis. The exterior PPy heterogeneous structure can be further doped with protons in the local acidic environment to intensify photoacoustic signals, allowing the non-invasive accurate tracking of tumors. The theranostic performance displayed negligible attenuated signals in near-infrared (NIR) windows. This organic-inorganic nanohybrid with a heterogeneous structure provides the potential to improve the overall outcomes of catalytic therapy.
Enhanced targeting reactivity and precise real-time monitoring are crucial for catalytic cancer therapy. Therefore, an activable organic-inorganic CeVO4-Ti@PPy nanohybrid is proposed, combining multiple simulated enzyme-like activities (chemodynamic therapy) and excellent photothermal effects to enhance catalytic cancer therapy. Additionally, the real-time and non-invasive visualization of tumors using photoacoustic imaging and photothermal imaging, enabling precise targeting therapy and monitoring. image |
| Keyword | cerium vanadate
chemodynamic therapy
polypyrrole
reactive oxygen species
theranostic
|
| DOI | 10.1002/adhm.202400830
|
| Indexed By | SCI
; EI
|
| Language | 英语
|
| WOS ID | WOS:001247833300001
|
| WOS Research Area | Engineering
; Science & Technology - Other Topics
; Materials Science
|
| WOS Subject | Engineering, Biomedical
; Nanoscience & Nanotechnology
; Materials Science, Biomaterials
|
| Funding Project | National Natural Science Foundation of China
; Postdoctoral Research Foundation of China[2019M652274]
; Qinglan Project of Jiangsu Province of China[2022]
; Postdoctoral Preferred Funding Project of Jiangxi[2019KY17]
; Scientific Research Foundation from Shenzhen Finance Bureau
; Joint Project of Industry-University-Research of Jiangsu Province[BY2021420]
; Joint Project of Industry-University-Research of Jiangsu Province[202304A0394]
; [51908252]
; [22305141]
; [82172044]
; [11972349]
; [11790292]
|
| Funding Organization | National Natural Science Foundation of China
; Postdoctoral Research Foundation of China
; Qinglan Project of Jiangsu Province of China
; Postdoctoral Preferred Funding Project of Jiangxi
; Scientific Research Foundation from Shenzhen Finance Bureau
; Joint Project of Industry-University-Research of Jiangsu Province
|
| Classification | 一类
|
| Ranking | 1
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| Citation statistics |
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| Document Type | 期刊论文
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| Identifier | http://dspace.imech.ac.cn/handle/311007/95664
|
| Collection | 非线性力学国家重点实验室
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Recommended Citation
GB/T 7714 |
Lu, Qianyun,Wang, Xiaotong,Fan, Xin,et al. Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic[J]. ADVANCED HEALTHCARE MATERIALS,2024:13.
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| APA |
Lu, Qianyun.,Wang, Xiaotong.,Fan, Xin.,林金国.,Hu, Jiayi.,...&Geng, Hongya.(2024).Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic.ADVANCED HEALTHCARE MATERIALS,13.
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| MLA |
Lu, Qianyun,et al."Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic".ADVANCED HEALTHCARE MATERIALS (2024):13.
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