Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices

doi:10.1016/j.physleta.2007.10.091

IMECH-IR > 力学所知识产出(1956-2008)

	Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices
	Zhang LM; Liu X(刘鑫); Liu, X (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
发表期刊	Physics Letters A
	2008
页码	2282-2285
ISSN	0375-9601
摘要	Here we attempt to characterize protein evolution by residue features which dominate residue substitution in homologous proteins. Evolutionary information contained in residue substitution matrix is abstracted with the method of eigenvalue decomposition. Top eigenvectors in the eigenvalue spectrums are analyzed as function of the level of similarity, i.e. sequence identity (SI) between homologous proteins. It is found that hydrophobicity and volume are two significant residue features conserved in protein evolution. There is a transition point at SI approximate to 45%. Residue hydrophobicity is a feature governing residue substitution as SI >= 45%. Whereas below this SI level, residue volume is a dominant feature. (C) 2007 Elsevier B.V. All rights reserved.
关键词	Protein Evolution Residue Feature Eigenvalue Decomposition Blosum Acid Substitution Matrices Protein Blocks
学科领域	生物力学
DOI	10.1016/j.physleta.2007.10.091
收录类别	SCI
语种	英语
WOS记录号	WOS:000254556800025
关键词[WOS]	ACID SUBSTITUTION MATRICES ; PROTEIN BLOCKS
WOS研究方向	Physics
WOS类目	Physics, Multidisciplinary
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/26084
专题	力学所知识产出(1956-2008)
通讯作者	Liu, X (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
推荐引用方式 GB/T 7714	Zhang LM,Liu X,Liu, X . Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices[J]. Physics Letters A,2008:2282-2285.
APA	Zhang LM,刘鑫,&Liu, X .(2008).Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices.Physics Letters A,2282-2285.
MLA	Zhang LM,et al."Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices".Physics Letters A (2008):2282-2285.

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