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| Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices | |
Zhang LM; Liu X(刘鑫) ; Liu, X (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
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| Source Publication | Physics Letters A
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| 2008 | |
| Pages | 2282-2285 |
| ISSN | 0375-9601 |
| Abstract | Here we attempt to characterize protein evolution by residue features which dominate residue substitution in homologous proteins. Evolutionary information contained in residue substitution matrix is abstracted with the method of eigenvalue decomposition. Top eigenvectors in the eigenvalue spectrums are analyzed as function of the level of similarity, i.e. sequence identity (SI) between homologous proteins. It is found that hydrophobicity and volume are two significant residue features conserved in protein evolution. There is a transition point at SI approximate to 45%. Residue hydrophobicity is a feature governing residue substitution as SI >= 45%. Whereas below this SI level, residue volume is a dominant feature. (C) 2007 Elsevier B.V. All rights reserved. |
| Keyword | Protein Evolution Residue Feature Eigenvalue Decomposition Blosum Acid Substitution Matrices Protein Blocks |
| Subject Area | 生物力学 |
| DOI | 10.1016/j.physleta.2007.10.091 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000254556800025 |
| WOS Keyword | ACID SUBSTITUTION MATRICES ; PROTEIN BLOCKS |
| WOS Research Area | Physics |
| WOS Subject | Physics, Multidisciplinary |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/26084 |
| Collection | 力学所知识产出(1956-2008) |
| Corresponding Author | Liu, X (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China. |
| Recommended Citation GB/T 7714 | Zhang LM,Liu X,Liu, X . Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices[J]. Physics Letters A,2008:2282-2285. |
| APA | Zhang LM,刘鑫,&Liu, X .(2008).Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices.Physics Letters A,2282-2285. |
| MLA | Zhang LM,et al."Significant Residue Features Revealed By Eigenvalue Decomposition Analysis Of Blosum Matrices".Physics Letters A (2008):2282-2285. |
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