Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution

doi:10.1016/j.febslet.2010.02.010

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	Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution
	Liu X(刘鑫); Zhao YP(赵亚溥); Zhao YP(赵亚溥)
发表期刊	FEBS Letters
	2010
卷号	584 期号:5 页码:1059-1065
ISSN	0014-5793
摘要	The molecular mechanics property is the foundation of many characters of proteins. Based on intramolecular hydrophobic force network, the representative family character underlying a protein’s mechanics property is described by a simple two-letter scheme. The tendency of a sequence to become a member of a protein family is scored according to this mathematical representation. Remote homologs of the WW-domain family could be easily designed using such a mechanistic signature of protein homology. Experimental validation showed that nearly all artificial homologs have the representative folding and bioactivity of their assigned family. Since the molecular mechanics property is the only consideration in this study, the results indicate its possible role in the generation of new members of a protein family during evolution.
学科领域	交叉与边缘领域的力学
DOI	10.1016/j.febslet.2010.02.010
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000274862900037
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/33082
专题	非线性力学国家重点实验室
通讯作者	Zhao YP(赵亚溥)
推荐引用方式 GB/T 7714	Liu X,Zhao YP,Zhao YP. Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution[J]. FEBS Letters,2010,584,5,:1059-1065.
APA	Liu X,Zhao YP,&赵亚溥.(2010).Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution.FEBS Letters,584(5),1059-1065.
MLA	Liu X,et al."Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution".FEBS Letters 584.5(2010):1059-1065.

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