| Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution | |
Liu X(刘鑫) ; Zhao YP(赵亚溥); Zhao YP(赵亚溥)
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| Source Publication | FEBS Letters
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| 2010 | |
| Volume | 584Issue:5Pages:1059-1065 |
| ISSN | 0014-5793 |
| Abstract | The molecular mechanics property is the foundation of many characters of proteins. Based on intramolecular hydrophobic force network, the representative family character underlying a protein’s mechanics property is described by a simple two-letter scheme. The tendency of a sequence to become a member of a protein family is scored according to this mathematical representation. Remote homologs of the WW-domain family could be easily designed using such a mechanistic signature of protein homology. Experimental validation showed that nearly all artificial homologs have the representative folding and bioactivity of their assigned family. Since the molecular mechanics property is the only consideration in this study, the results indicate its possible role in the generation of new members of a protein family during evolution. |
| Subject Area | 交叉与边缘领域的力学 |
| DOI | 10.1016/j.febslet.2010.02.010 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000274862900037 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/33082 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Zhao YP(赵亚溥) |
| Recommended Citation GB/T 7714 | Liu X,Zhao YP,Zhao YP. Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution[J]. FEBS Letters,2010,584,5,:1059-1065. |
| APA | Liu X,Zhao YP,&赵亚溥.(2010).Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution.FEBS Letters,584(5),1059-1065. |
| MLA | Liu X,et al."Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution".FEBS Letters 584.5(2010):1059-1065. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| FEBS33843.pdf（895KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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