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Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation 期刊论文
BMC BIOLOGY, 2024, 卷号: 22, 期号: 1, 页码: 262./通讯作者：Lue DY, Long M
Authors:  Zhong SY(钟绍宇);  Zheng L(郑璐);  Wu Y(武亿);  Sun SJ(孙树津);  Luo, Qing;  Song, Guanbin;  Lv DY(吕东媛);  Long M(龙勉)
Favorite  |  View/Download：20/0  |  Submit date：2024/12/02
Liver organoids  HepaRG cells  Rotating Flat Chamber  Rotating culture  YAP  Mechanotransduction  
Stretch-induced hepatic endothelial mechanocrine promotes hepatocyte proliferation 期刊论文
HEPATOLOGY, 2024./通讯作者：Lü DY, Long M
Authors:  Wu Y(武亿);  Li LD(李林达);  Li, Wang;  Li N(李宁);  Zhang XY(张晓宇);  Zheng L(郑璐);  Zhong SY(钟绍宇);  Lv SQ(吕守芹);  Shu XY(舒芯钰);  Zhou J(周瑾);  Ai, Ding;  Gao, Ming;  Liu, Sijin;  Lv DY(吕东媛);  Long M(龙勉)
Favorite  |  View/Download：34/0  |  Submit date：2024/12/02
HB-EGF  liver regeneration  liver sinusoidal endothelial cell  mechanotransduction  mechanical stretch  
FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration 期刊论文
BIOMATERIALS, 2024, 卷号: 305, 页码: 17./通讯作者：Li, Ning, Long, Mian
Authors:  Zhang XY(张晓宇);  Li PW(李培文);  Zhou J(周瑾);  Zhang ZL(张子良);  Wu H(吴欢);  Shu XY(舒芯钰);  Li W(李旺);  Wu Y(武亿);  Du Y(杜宇);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
Favorite  |  View/Download：100/0  |  Submit date：2024/04/02
Liver sinusoidal endothelial cells  Fenestrae  Liver fibrosis  Cytoskeleton remodeling  FAK  MAPK  
Direct mechanical exposure initiates hepatocyte proliferation 期刊论文
JHEP REPORTS, 2023, 卷号: 5, 期号: 12, 页码: 13./通讯作者：Li, Ning, Long, Mian
Authors:  Li, Wang;  Wu Y(武亿);  Hu, Wenhui;  Zhou J(周瑾);  Shu XY(舒芯钰);  Zhang XY(张晓宇);  Zhang, Ziliang;  Wu, Huan;  Du, Yu;  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
Adobe PDF(3334Kb)  |  Favorite  |  View/Download：149/44  |  Submit date：2024/01/02
Mechanotransduction  FAK  hepatic sinusoid chip  
Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 3, 页码: 20./通讯作者：李宁，龙勉
Authors:  Li W(李旺);  Shu XY(舒芯钰);  Zhang XY(张晓宇);  Zhang ZL(张子良);  Sun SJ(孙树津);  Li N(李宁);  Long M(龙勉)
Adobe PDF(1498Kb)  |  Favorite  |  View/Download：190/30  |  Submit date：2023/03/20
microgravity  liver metabolism  mechanosensing  cytoskeleton  nuclear deformation  phase separation  
Data-driven turbulence model for unsteady cavitating flow 期刊论文
PHYSICS OF FLUIDS, 2023, 卷号: 35, 期号: 1, 页码: 18./通讯作者：Wang, Yiwei
Authors:  Zhang Z(张珍);  Wang JZ(王静竹);  Huang RF(黄仁芳);  Qiu RD(丘润荻);  Chu, Xuesen;  Ye SR(叶舒然);  Wang YW(王一伟);  Liu, Qingkuan
Adobe PDF(4681Kb)  |  Favorite  |  View/Download：330/62  |  Submit date：2023/02/27
Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer 期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448./通讯作者：Long, M (corresponding author), Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China.
Authors:  Li N(李宁);  Zhang XY(张晓宇);  Zhou J(周瑾);  Li W(李旺);  Shu XY(舒芯钰);  Wu Y(武亿);  Long M(龙勉)
Adobe PDF(2553Kb)  |  Favorite  |  View/Download：476/171  |  Submit date：2022/10/23
Liver tissue stiffness  Shear stress  Hydrostatic pressure  Hepatocytes  Hepatocellular carcinoma  Liver sinusoidal endothelial cells  Hepatic stellate cells  Mechanotransduction pathways  Mechanomedicine  Drug design and delivery  
一种全密闭细胞基底拉伸和流动剪切复合加载实验系统 专利
发明授权.一种全密闭细胞基底拉伸和流动剪切复合加载实验系统, 授权公告号: CN111423980B, 申请日期: 2020-04-08, 授权公告日期: 2022-03-15
Inventors:  孙树津;  龙勉
Adobe PDF(355Kb)  |  Favorite  |  View/Download：184/64  |  Submit date：2022/10/09
一种可扩张基底细胞连续扩增培养器 专利
发明授权.一种可扩张基底细胞连续扩增培养器, 授权公告号: CN111423983B, 申请日期: 2020-04-08, 授权公告日期: 2022-03-15
Inventors:  孙树津;  龙勉
Adobe PDF(517Kb)  |  Favorite  |  View/Download：262/110  |  Submit date：2022/10/09
Gravity-Vector Induces Mechanical Remodeling of rMSCs via Combined Substrate Stiffness and Orientation 期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 卷号: 9, 页码: 14./通讯作者：Long, Mian
Authors:  Zhang C(张晨);  Lv DY(吕东媛);  Zhang F(张帆);  Wu Y(武亿);  Zheng L(郑鲁);  Zhang XY(张晓宇);  Li Z(李展);  Sun SJ(孙树津);  龙勉Mian
Adobe PDF(3580Kb)  |  Favorite  |  View/Download：214/71  |  Submit date：2022/05/17
substrate stiffness  orientation  mechanosensing  nucleus translocation  cytoskeletal remodeling  focal adhesion complex reorganization  cellular morphology